Methane → HCID 12900686, compound

HRID 1155694Notes

Reaction equation

HRID 1155694 reaction equation
[ClH:1].[NH:2]1[C:10]2[C:5](=[C:6]([C:11]3([OH:24])[CH2:16][CH2:15][CH2:14][N:13](CC4C=CC=CC=4)[CH2:12]3)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.C>CO>[ClH:1].[NH:2]1[C:10]2[C:5](=[C:6]([C:11]3([OH:24])[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]3)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1

Participants

4

Reactant 2

HCID 297MethaneHCID 12900684HCID 12900684, compound

Product 1

HCID 12900686HCID 12900686, compoundYield 96.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

12.7 g of the hydrochloride of Step C in 500 ml of methanol were hydrogenated at 60° C. in the presence of 3.6 g of palladized active charcoal and the mixture was filtered. The filtrate was concentrated to dryness to obtain 9 g of 3-(1H-indol-4-yl)-3-piperidinol hydrochloride which was used as is for the next step.

Workup

  1. filtrationthe mixture was filtered
  2. concentrationThe filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-8678530feb0d4bcfb27a6ba5ae904f0a
Source dataset
uspto-grants-1982_06
Patent number
US04332808

Reaction notes

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