1,1'-Carbonyldiimidazole → HCID 178426987, compound

HRID 1155698Notes

Reaction equation

HRID 1155698 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([N:14]([CH3:16])[CH3:15])=[CH:10][CH:9]=2)[N:5]=[C:4]([C:17]([OH:19])=O)[CH:3]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:32][C:33]1[NH:37][N:36]=[N:35][N:34]=1>>[NH:34]1[C:33]([NH:32][C:17]([C:4]2[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([C:8]3[CH:9]=[CH:10][C:11]([N:14]([CH3:15])[CH3:16])=[CH:12][CH:13]=3)[N:5]=2)=[O:19])=[N:37][N:36]=[N:35]1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 20537526HCID 20537526, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178426987HCID 178426987, compoundYield 19%

Procedure

In the same manner as described in Example 1-(1), 4-methyl-6-(4-dimethylaminophenyl)-2-pyridinecarboxylic acid (1.25 g), carbonyldiimidazole (1.38 g) and 5-aminotetrazole (0.47 g) are reacted to give N-(5-tetrazolyl)-4-methyl-6-(4-dimethylaminophenyl)-2-pyridinecarboxamide (0.3 g). M.P. 265°-269° C. (decomp.) (wetted from 255° C.) (recrystallized from dimethylformamide-ethanol)

Sources & evidence

ORD record
ord-91d5e47bc95c419caaea3a3b9cb03b42
Source dataset
uspto-grants-1982_06
Patent number
US04332809

Reaction notes

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