1,1'-Carbonyldiimidazole → HCID 178463799, compound

HRID 1155699Notes

Reaction equation

HRID 1155699 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])=[CH:10][CH:9]=2)[N:5]=[C:4]([C:19]([OH:21])=O)[CH:3]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:34][C:35]1[NH:39][N:38]=[N:37][N:36]=1>>[NH:36]1[C:35]([NH:34][C:19]([C:4]2[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([C:8]3[CH:9]=[CH:10][C:11]([N:14]([CH2:15][CH3:16])[CH2:17][CH3:18])=[CH:12][CH:13]=3)[N:5]=2)=[O:21])=[N:39][N:38]=[N:37]1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 12811137HCID 12811137, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178463799HCID 178463799, compoundYield 65.5%

Procedure

In the same manner as described in Example 1-(1), 4-methyl-6-(4-diethylaminophenyl)-2-pyridinecarboxylic acid (1.0 g), carbonyldiimidazole (1.0 g) and 5-aminotetrazole (0.32 g) are reacted to give N-(5-tetrazolyl)-4-methyl-6-(4-diethylaminophenyl)-2-pyridinecarboxamide (0.81 g). M.P. 254°-256° C. (decomp.) (recrystallized from dimethylformamide-ethanol)

Sources & evidence

ORD record
ord-21e0cd6dad134c52b49c30aff8b1ac4a
Source dataset
uspto-grants-1982_06
Patent number
US04332809

Reaction notes

Loading…