1,1'-Carbonyldiimidazole → HCID 178463259, compound

HRID 1155702Notes

Reaction equation

HRID 1155702 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][CH2:17][CH3:18])=[CH:12][CH:11]=2)[N:7]=[C:6]([C:19]([OH:21])=O)[CH:5]=1)[CH3:2].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:34][C:35]1[NH:39][N:38]=[N:37][N:36]=1>>[NH:36]1[C:35]([NH:34][C:19]([C:6]2[CH:5]=[C:4]([O:3][CH2:1][CH3:2])[CH:9]=[C:8]([C:10]3[CH:11]=[CH:12][C:13]([NH:16][CH2:17][CH3:18])=[CH:14][CH:15]=3)[N:7]=2)=[O:21])=[N:39][N:38]=[N:37]1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 20537506HCID 20537506, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178463259HCID 178463259, compoundYield 69.5%

Procedure

In the same manner as described in Example 1-(1), 4-ethoxy-6-(4-ethylaminophenyl)-2-pyridinecarboxylic acid (0.28 g), carbonyldiimidazole (0.17 g) and 5-aminotetrazole (0.09 g) are reacted to give N-(5-tetrazolyl)-4-ethoxy-6-(4-ethylaminophenyl)-2-pyridinecarboxamide (0.24 g). M.P. 255°-257° C. (decomp.) (recrystallized from dimethylformamide-ethanol)

Sources & evidence

ORD record
ord-d03adf656df44b979e0d679c64b69c3a
Source dataset
uspto-grants-1982_06
Patent number
US04332809

Reaction notes

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