反应详情

温度

95 °C

A mixture of 10-oxo-10H-pyrido[1,2-a]thieno[3,4-d]pyrimidine-7-carboxamide (3.8 g., 0.015 mol), p-toluenesulfonyl chloride (4.4 g., 0.023 mol) and pyridine (3.8 ml, 0.046 mol) in dimethylformamide (50 ml) is heated at 95° C. for 1 hour. The mixture is cooled, diluted with water (5 ml) and stirred. The precipitate is filtered, washed with water and dried. Recrystallization from 2-propanol gives golden crystals (2.5 g.) mp 233°-234° C.

1. temperatureThe mixture is cooled
2. filtrationThe precipitate is filtered
3. washwashed with water
4. customdried
5. customRecrystallization from 2-propanol
6. customgives golden crystals (2.5 g.) mp 233°-234° C.