Hydrochloric Acid → HCID 131711939, compound

HRID 1155921Notes

Reaction equation

HRID 1155921 reaction equation
[CH2:1]([C:3]1[S:19][C:6]2[N:7]=[C:8]3[CH:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][N:9]3[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2].[ClH:20].CCOCC>CC(O)C>[ClH:20].[CH2:1]([C:3]1[S:19][C:6]2[N:7]=[C:8]3[CH:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][N:9]3[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 12862351HCID 12862351, compound

Product 1

HCID 131711939HCID 131711939, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

To a cooled solution of 2-ethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid (Example 2), 0.2 g (0.00073 mol), in 50 ml of 2-propanol, is added a slight excess of a solution of dry hydrogen chloride in 2-propanol. After 10 minutes, 500 ml of anhydrous ether is added to the previous solution and the precipitate filtered to give 0.1 g of 2-ethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid, monohydrochloride; mp 255°-256° C. after recrystallization from 2-propanol-ether.

Workup

  1. filtrationthe precipitate filtered

Sources & evidence

ORD record
ord-3895535124fd49c6a6ba5aa014795568
Source dataset
uspto-grants-1982_06
Patent number
US04332947

Reaction notes

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