Hydrazine hydrate (1:1) → HCID 20536176, compound

HRID 1155936Notes

Reaction equation

HRID 1155936 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:11]=2[NH:19][C:20](=[O:22])[CH3:21])C(=O)C2=CC=CC=C12.O.NN>C(O)CC>[NH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:11]=1[NH:19][C:20](=[O:22])[CH3:21]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20536169HCID 20536169, compound

Product 1

HCID 20536176HCID 20536176, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Conditions

Temperature
0 °C

Procedure

0.03 mol (11.5 g) of 2-acetylamino-4-nitrophenyl γ-phthalimidopropyl ether and 3 cm3 of 98% pure hydrazine hydrate in 120 cm3 of normal propyl alcohol are heated for 15 minutes on a boiling waterbath. After hot filtration, the filtrate is cooled to 0° C. The expected product precipitates. It is taken up in a dilute solution of sodium hydroxide, and the sodium hydroxide phase is extracted with chloroform. By concentrating the solvent in vacuo, the expected product, which melts at 110°-120° C., is obtained.

Workup

  1. filtrationAfter hot filtration
  2. customThe expected product precipitates
  3. extractionthe sodium hydroxide phase is extracted with chloroform
  4. concentrationBy concentrating the solvent in vacuo

Sources & evidence

ORD record
ord-01f5ff3b3e6648538f7aab8d76abfd9a
Source dataset
uspto-grants-1982_06
Patent number
US04333730

Reaction notes

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