Water → HCID 54023141, compound

HRID 1156068Notes

Reaction equation

HRID 1156068 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]([O-:11])=[O:10])[C:3]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[Na+].[CH2:19](I)[CH3:20].O>CN(C)C=O>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]([O:11][CH2:19][CH3:20])=[O:10])[C:3]=1[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 962WaterHCID 6340IodoethaneHCID 23702198HCID 23702198, compound

Product 1

HCID 54023141HCID 54023141, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Sodium 2-amino-6-biphenylacetate is dissolved in dimethylformamide and the solution treated with ethyliodide. The solution is stirred at room temperature for about 3 hours, the solution added to water and the mixture extracted several times with benzene. The combined benzene extracts are washed with dilute base and water, dried over sodium sulfate, concentrated under reduced pressure and crystallized to give ethyl 2-amino-6-biphenylacetate.

Workup

  1. extractionthe mixture extracted several times with benzene
  2. washThe combined benzene extracts are washed
  3. additionwith dilute base and water
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customcrystallized

Sources & evidence

ORD record
ord-e1f8731b38df4380937b8181ca35bd7e
Source dataset
uspto-grants-1982_06
Patent number
US04333951

Reaction notes

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