反应详情

In 20 ml tetrahydrofuran were dissolved 0.8 g (0.0075 mol) of ethyl thioethanol and 0.8 g (0.0079 mol) of triethylamine, and while heating to 60°-80° C., 1.6 g (0.0043 mol) of 2-chloro-5-(2-chloro-4-trifluoromethylphenoxy)benzoyl chloride was added. After 5-hour stirring, the resulting mixture was cooled, freed of the solvent under reduced pressure, and extracted with benzene. The extract was washed with a dilute aqueous solution of caustic soda and then with dilute hydrochloric acid, and dehydrated with sodiumsulfate. By concentration, 1.0 g (0.0023 mol) of the intended product was obtained as an oily substance; yield 53.0%, nD23 1.5500.

1. temperaturewhile heating to 60°-80° C.
2. temperaturethe resulting mixture was cooled
3. extractionextracted with benzene
4. washThe extract was washed with a dilute aqueous solution of caustic soda
5. concentrationBy concentration