Triethylamine → HCID 13037973, compound

HRID 1156406Notes

Reaction equation

HRID 1156406 reaction equation
Cl.[NH2:2][CH:3]([C:8]([NH:10][C:11]1[S:12][CH:13]=[N:14][N:15]=1)=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6].C(N(CC)CC)C.[Cl:23][CH2:24][CH2:25][N:26]=[C:27]=[O:28]>O1CCCC1>[Cl:23][CH2:24][CH2:25][NH:26][C:27]([NH:2][CH:3]([C:8]([NH:10][C:11]1[S:12][CH:13]=[N:14][N:15]=1)=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6])=[O:28]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 160352-Chloroethyl isocyanateHCID 20503547HCID 20503547, compound

Product 1

HCID 13037973HCID 13037973, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7.5 g of 2-DL-leucylamino-1,3,4-thiadiazole hydrochloride and 3.1 g of triethylamine were suspended in 100 ml of tetrahydrofuran, and 3.2 g of 2-chloroethyl isocyanate was added thereto and stirred for 2 hours. The reaction solution was concentrated, and the resulting crystals were washed with water and n-hexane to obtain 7.9 g (Yield 83%) of 2-[N-{(2-chloroethyl)carbamoyl}-DL-leucyl]amino-1,3,4-thiadiazole was obtained as slightly yellow crystals having a melting point of from 162° to 166° C. (dec.).

Workup

  1. concentrationThe reaction solution was concentrated
  2. washthe resulting crystals were washed with water and n-hexane

Sources & evidence

ORD record
ord-fb41689decd34268b4a337d29d4346e7
Source dataset
uspto-grants-1982_06
Patent number
US04335247

Reaction notes

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