Dimethylformamide → HCID 12960033, compound

HRID 1156528Notes

Reaction equation

HRID 1156528 reaction equation
[C:1]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][C:4]([C:7]2[O:11][N:10]=[C:9]([NH2:12])[CH:8]=2)=[CH:3][CH:2]=1.[Cl:19][C:20]1[CH:30]=[CH:29][CH:28]=[C:27]([Cl:31])[C:21]=1[C:22]([N:24]=[C:25]=[O:26])=[O:23].CN(C=O)C>O>[Cl:19][C:20]1[CH:30]=[CH:29][CH:28]=[C:27]([Cl:31])[C:21]=1[C:22]([NH:24][C:25]([NH:12][C:9]1[CH:8]=[C:7]([C:4]2[CH:5]=[CH:6][C:1]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:2][CH:3]=2)[O:11][N:10]=1)=[O:26])=[O:23]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 129127392,6-Dichlorobenzoyl isocyanateHCID 12960032HCID 12960032, compound

Product 1

HCID 12960033HCID 12960033, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-(4-Biphenylyl)-3-aminoisoxazole (450 mg.) was mixed with excess 2,6-dichlorobenzoyl isocyanate in 50 ml. of DMF and the reaction mixture stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into water and the product separated by filtration and recrystallized from ethanol, m.p. 225°-227° C.

Workup

  1. customthe product separated by filtration
  2. customrecrystallized from ethanol, m.p. 225°-227° C.

Sources & evidence

ORD record
ord-788a4e99153a4742b544692c5d3640db
Source dataset
uspto-grants-1982_06
Patent number
US04336264

Reaction notes

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