2,6-Dichlorobenzoyl isocyanate → HCID 12960044, compound

HRID 1156530Notes

Reaction equation

HRID 1156530 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([C:9]2[O:13][N:12]=[C:11]([NH2:14])[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.[Cl:17][C:18]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:19]=1[C:20]([N:22]=[C:23]=[O:24])=[O:21]>C(OCC)(=O)C>[Cl:17][C:18]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:19]=1[C:20]([NH:22][C:23]([NH:14][C:11]1[CH:10]=[C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:15])[F:16])[CH:4]=2)[O:13][N:12]=1)=[O:24])=[O:21]

Participants

4

Reactant 2

HCID 129127392,6-Dichlorobenzoyl isocyanateHCID 12960073HCID 12960073, compound

Product 1

HCID 12960044HCID 12960044, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-(3-(Trifluoromethyl)phenyl)-3-aminoisoxazole (300 mg.) and excess 2,6-dichlorobenzoyl isocyanate were mixed in 50 ml. of ethyl acetate under nitrogen, and stirred for several hours at room temperature. The product was separated by filtration, m.p., 233° C. (dec)

Workup

  1. customThe product was separated by filtration, m.p., 233° C. (dec)

Sources & evidence

ORD record
ord-98c0fba7bb944708b6ed70d380580e46
Source dataset
uspto-grants-1982_06
Patent number
US04336264

Reaction notes

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