2-Chlorobenzoyl isocyanate → HCID 12960062, compound

HRID 1156532Notes

Reaction equation

HRID 1156532 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][N:14]=[C:13]([NH2:16])[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:17][C:18]1[CH:28]=[CH:27][CH:26]=[CH:25][C:19]=1[C:20]([N:22]=[C:23]=[O:24])=[O:21]>C(OCC)(=O)C>[Cl:17][C:18]1[CH:28]=[CH:27][CH:26]=[CH:25][C:19]=1[C:20]([NH:22][C:23]([NH:16][C:13]1[CH:12]=[C:11]([C:8]2[CH:7]=[CH:6][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:10][CH:9]=2)[O:15][N:14]=1)=[O:24])=[O:21]

Participants

4

Reactant 2

HCID 99423112-Chlorobenzoyl isocyanateHCID 12960074HCID 12960074, compound

Product 1

HCID 12960062HCID 12960062, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-(4-tert-Butylphenyl)-3-aminoisoxazole (1 gram) and 2 chlorobenzoyl isocyanate (1.5 ml.) were mixed in 50 ml. of ethyl acetate. The reaction mixture was stirred for 3 hours at room temperature, solvent removed, and the product separated by filtration, m.p., 213°-214° C.

Workup

  1. customsolvent removed
  2. customthe product separated by filtration, m.p., 213°-214° C.

Sources & evidence

ORD record
ord-9405b66d13554b2289ef92bdef8c2a4e
Source dataset
uspto-grants-1982_06
Patent number
US04336264

Reaction notes

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