2-Methylbenzenesulfonic acid → HCID 86738432, compound

HRID 1156572Notes

Reaction equation

HRID 1156572 reaction equation
[C:1]([C:4]1[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:6][O:7][C:8]=1[CH3:9])(=O)[CH3:2].[C:16]1([NH:22][NH2:23])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C1(C)C(S(O)(=O)=O)=CC=CC=1>C(O)C>[C:16]1([NH:22][N:23]=[C:1]([C:4]2[C:5]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:6][O:7][C:8]=2[CH3:9])[CH3:2])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 69252-Methylbenzenesulfonic acidHCID 7516PhenylhydrazineHCID 3185241-(5-Methyl-3-phenylisoxazol-4-yl)ethanone

Product 1

HCID 86738432HCID 86738432, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 80.4 g. (0.4 mole) of 4-acetyl-5-methyl-3-phenyl isoxazole, 39.4 ml. (0.4 mole) of phenyl hydrazine and 500 mg. toluenesulfonic acid in 400 ml. ethanol is stirred at room temperature for 48 hours. The resulting solid is filtered and washed with cold ether to give 1-(5-methyl-3-phenyl-4-isoxazolyl)-1-ethanone phenyl hydrazone; m.p. 129°-133° C.

Workup

  1. additionA mixture of 80.4 g
  2. filtrationThe resulting solid is filtered
  3. washwashed with cold ether

Sources & evidence

ORD record
ord-3a157e8ee4ac4209bf319890f75cb5b2
Source dataset
uspto-grants-1982_06
Patent number
US04336378

Reaction notes

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