Acetyl chloride → HCID 12851604, compound

HRID 1156719Notes

Reaction equation

HRID 1156719 reaction equation
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[N:3]=1.[C:11](Cl)(=[O:13])[CH3:12]>C1(C)C(C)=CC=CC=1>[C:11]([NH:1][C:2]1[S:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[N:3]=1)(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 205336525-amino-3-trifluoromethyl-1,2,4-thiadiazole

Product 1

HCID 12851604HCID 12851604, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 4.3 grams (0.05 mole) 5-amino-3-trifluoromethyl-1,2,4-thiadiazole and 7.0 grams (0.09 mole) acetyl chloride in 50 milliliters xylene was refluxed at about 140° C. for 20 hours. Upon cooling to room temperature 2.9 grams (55% yield) pure product precipitated; m.p. 178.1° C.

Sources & evidence

ORD record
ord-8eb2c057cda341d8a5c33af5de18b25e
Source dataset
uspto-grants-1982_06
Patent number
US04337081

Reaction notes

Loading…