HCID 53908529, compound → HCID 53869724, compound

HRID 1156728Notes

Reaction equation

HRID 1156728 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:10]([N:11]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[N+:20]([O-])=O)[CH3:12])=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4]>[Ni].C(OCC)(=O)C>[CH3:1][O:2][C:3]([C:5]1[C:10]([N:11]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[NH2:20])[CH3:12])=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4]

Participants

4

Reactant 1

HCID 53908529HCID 53908529, compound

Product 1

HCID 53869724HCID 53869724, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 4.0 g 3-(4-chloro-N-methyl-2-nitrophenylamino)-pyrazine-2-carboxylic acid methyl ester, 200 ml ethyl acetate and 4 g Raney Nickel are hydrogenated at room temperature under normal pressure. The catalyst is removed by filtration and the filtrate is evaporated to afford the heading compound. It is used without further purification.

Workup

  1. customare hydrogenated at room temperature under normal pressure
  2. customThe catalyst is removed by filtration
  3. customthe filtrate is evaporated
  4. customto afford the heading compound
  5. customIt is used without further purification

Sources & evidence

ORD record
ord-2c2e967c719142e19c74d0821f2f409b
Source dataset
uspto-grants-1982_06
Patent number
US04337198

Reaction notes

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