反应详情

To a solution of 1.3 g of methyl 5-chloroanthranilate and 1.8 g of 3,4,5-trimethoxybenzoylchloride in 30 ml of tetrahydrofuran is added 1.5 g of triethylamine under cooling, and the mixture is stirred at room temperature for 2 hours and then heated under reflux for 1 hour. The reaction mixture is concentrated under reduced pressure and to the residue is added water. The precipitated crystals are collected by filtration and recrystallized from a mixture of chloroform and ether to obtain 1.4 g of methyl N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilate as colorless prisms.

1. temperatureunder cooling
2. temperatureheated
3. temperatureunder reflux for 1 hour
4. concentrationThe reaction mixture is concentrated under reduced pressure and to the residue
5. additionis added water
6. filtrationThe precipitated crystals are collected by filtration
7. customrecrystallized from a mixture of chloroform and ether