反应详情

1-(4-Chlorophenyl)isoquinoline-5-acetonitrile (2.6 g) was dissolved in 20 ml of diethyl carbonate, and 1.0 g of 50% oily sodium hydride was added. Then, 10 ml of dimethylsulfoxide was added, and 1.5 g of methyl iodide was added under cooling with water. The mixture was stirred for 1 hour. The reaction mixture was poured into water, extracted with ether, and dried. The solvent was distilled off. The resulting oily product was recrystallized from ether-hexane to afford ethyl 2-[1-(4-chlorophenyl)isoquinolin-5-yl]-2-cyanopropionate as colorless prisms having a melting point of 92° to 93.5° C.

1. extractionextracted with ether
2. customdried
3. distillationThe solvent was distilled off
4. customThe resulting oily product was recrystallized from ether-hexane