Ethanol → HCID 53943974, compound

HRID 1156937Notes

Reaction equation

HRID 1156937 reaction equation
[CH:1]([C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([CH2:14][C:15]([OH:17])=[O:16])[C:8]=2[CH:7]=[CH:6][N:5]=1)([CH3:3])[CH3:2].S(=O)(=O)(O)O.C(=O)([O-])[O-].[K+].[K+].[CH2:29](O)[CH3:30]>>[CH:1]([C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([CH2:14][C:15]([O:17][CH2:29][CH3:30])=[O:16])[C:8]=2[CH:7]=[CH:6][N:5]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 4

HCID 702EthanolHCID 1118Sulfuric AcidHCID 11430Potassium CarbonateHCID 12832773HCID 12832773, compound

Product 1

HCID 53943974HCID 53943974, compound

Procedure

1-iso-Propylisoquinoline-5-acetic acid (0.5 g) was dissolved in 20 ml of ethanol, and 3 ml of conc. sulfuric acid was added. The mixture was heated under reflux for 3 hours. The reaction mixture was poured into ice water, made weakly alkaline with potassium carbonate, extracted with benzene, washed in water, and dried. The solvent was distilled off under reduced pressure to afford 0.5 g of ethyl 1-isopropylisoquinoline-5-acetate as a colorless oil.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. extractionextracted with benzene
  4. washwashed in water
  5. customdried
  6. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-b991aeff7dc642deae10718d8c2c2638
Source dataset
uspto-grants-1982_06
Patent number
US04337256

Reaction notes

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