反应详情

To a solution of 1-benzyloxy-2-bromo-4-nitrobenzene (50 mg, 0.16 mmol) in ethanol (5 mL) and H2O (0.5 mL) was added iron (134 mg, 2.43 mmol) and one drop of concentrated HCl. The mixture was refluxed for 6 hrs and filtrated. The filtrate was diluted with ethyl acetate, washed with saturated sodium bicarbonated solution, dried over sodium sulfate and concentrated to afford crude 4-amino-1-benzyloxy-2-bromobenzene.

1. temperatureThe mixture was refluxed for 6 hrs
2. filtrationfiltrated
3. additionThe filtrate was diluted with ethyl acetate
4. washwashed with saturated sodium bicarbonated solution
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated