反应详情

1-{2-Oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid methyl ester (compound 11 from Step 8, 3.3 gm, 8.06 mmol) was dissolved in methanol and 10 ml of 1 N lithium hydroxide added. The reaction mixture was stirred for 18 hrs. 10 ml of 1 N HCl was added to the reaction mixture and evaporated to a white solid (3.94 gm)

1. customevaporated to a white solid (3.94 gm)