反应详情

To sodium hydride (0.20 g) taken in THF (15 ml), morpholine (0.735 ml) was added under nitrogen, at 0° C. The reaction mixture stirred for about 15 minutes, then 2,3-dibromopyrazine (2 g) dissolved in dry THF (15 ml) was added. The reaction mixture was allowed to stir at reflux conditions for overnight. The reaction mixture was quenched with water (5 ml), and volatiles were removed under vacuum. The resulting crude mass was purified by column chromatography to afford pure 4-(5-bromopyrazin-2-yl)morpholine.

1. additionwas added
2. stirringto stir
3. temperatureat reflux conditions for overnight
4. customThe reaction mixture was quenched with water (5 ml), and volatiles
5. customwere removed under vacuum
6. customThe resulting crude mass was purified by column chromatography