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温度

0 °C

To sodium hydride (0.20 g) in THF (15 ml), imidazole (0.57 g) was added and cooled to 0° C. To the above mixture 2,3-dibromopyrazine (2 g) was added and entire reaction mixture was allowed to reflux for overnight. The reaction mixture was quenched with water 5 ml volatiles were removed under vacuum. The resulting crude mass was purified by column chromatography to afford 2-bromo-5-(1H-imidazol-1-yl)pyrazine as pure product.

1. temperatureto reflux for overnight
2. customThe reaction mixture was quenched with water 5 ml volatiles
3. customwere removed under vacuum
4. customThe resulting crude mass was purified by column chromatography