反应详情

A mixture of 750 mg (3.63 mmol) of 4-amino-3-chlorobenzenesulfonamide (A-2) and 610 mg (7.26 mmol) of sodium bicarbonate in 25 mL of CH2Cl2 was stirred at room temperature for 18 hours. Bromoacetyl bromide (A-1) was then added, and the mixture was stirred for an additional 12 hours. The mixture was then concentrated in vacuo to a yellow oil. The oil was washed with three 25 mL portions of diethyl ether, decanted, and concentrated in vacuo to give the desired product A-3 as a tan solid. MS: M+1=329.0.

1. stirringthe mixture was stirred for an additional 12 hours
2. concentrationThe mixture was then concentrated in vacuo to a yellow oil
3. washThe oil was washed with three 25 mL portions of diethyl ether
4. customdecanted
5. concentrationconcentrated in vacuo