Hydrochloric Acid → HCID 68521714, compound

HRID 1157448Notes

Reaction equation

HRID 1157448 reaction equation
C[O:2][C:3](=[O:24])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:7]=[CH:6][C:5]=1[NH:20]C(=O)C.[ClH:25]>>[ClH:25].[ClH:25].[NH2:20][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:9][C:4]=1[C:3]([OH:24])=[O:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 685239932-Acetylamino-5-(3-piperidin-1-ylpropoxy)benzoic acid methyl ester

Product 1

HCID 68521714HCID 68521714, compoundYield 100%

Procedure

2-Acetylamino-5-(3-piperidin-1-ylpropoxy)benzoic acid methyl ester (1.34 g, 4.0 mmol) was treated with 6N HCl (aq.) (20 mL) and heated at reflux temperature for 8 h. The mixture was then cooled and concentrated in vacuo to afford 2-amino-5-(3-piperidin-1-ylpropoxy)benzoic acid dihydrochloride (1.4 g, 4.0 mmol, 100%).

Workup

  1. temperatureheated
  2. temperatureat reflux temperature for 8 h
  3. temperatureThe mixture was then cooled
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-aa917166df5442a0a708e41c046e9ad6
Source dataset
uspto-grants-2010_10
Patent number
US07807686B2

Reaction notes

Loading…