反应详情

2-Acetylamino-5-(3-piperidin-1-ylpropoxy)benzoic acid methyl ester (1.34 g, 4.0 mmol) was treated with 6N HCl (aq.) (20 mL) and heated at reflux temperature for 8 h. The mixture was then cooled and concentrated in vacuo to afford 2-amino-5-(3-piperidin-1-ylpropoxy)benzoic acid dihydrochloride (1.4 g, 4.0 mmol, 100%).

1. temperatureheated
2. temperatureat reflux temperature for 8 h
3. temperatureThe mixture was then cooled
4. concentrationconcentrated in vacuo