Chloride → HCID 57737247, compound

HRID 1157554Notes

Reaction equation

HRID 1157554 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([NH:12][C:13]2[N:18]=[C:17]([C:19]3[C:20]([C:28]4[CH:29]=[C:30]([NH:34]C(=O)C(F)(F)F)[CH:31]=[CH:32][CH:33]=4)=[N:21][N:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=34)[CH:16]=[CH:15][N:14]=2)[CH:9]=[CH:10][CH:11]=1.[Cl-].[NH:42]1[CH2:47][CH2:46][O:45][CH2:44][CH2:43]1>>[NH2:34][C:30]1[CH:29]=[C:28]([C:20]2[C:19]([C:17]3[CH:16]=[CH:15][N:14]=[C:13]([NH:12][C:8]4[CH:9]=[CH:10][CH:11]=[C:6]([O:5][CH2:4][CH2:3][CH2:2][N:42]5[CH2:47][CH2:46][O:45][CH2:44][CH2:43]5)[CH:7]=4)[N:18]=3)=[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][N:22]3[N:21]=2)[CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 3

HCID 312ChlorideHCID 8083MorpholineHCID 59511411HCID 59511411, compound

Product 1

HCID 57737247HCID 57737247, compoundYield 71%

Procedure

The compound was synthesized from N-(3-{3-[2-({3-[(3-chloropropyl)oxy]-phenyl}amino)-4-pyrimidinyl]pyrazolo[1,5-a]pyridin-2-yl}phenyl)-2,2,2-trifluoroacetamide via chloride displacement with morpholine as described in Example 10, Step D to afford an orange solid in 71% yield. ES-LC/MS m/z 522 [M+H]+.

Workup

  1. customto afford an orange solid in 71% yield

Sources & evidence

ORD record
ord-1c5b9a4c3cf34991803aba11a95373ab
Source dataset
uspto-grants-2010_10
Patent number
US07807673B2

Reaction notes

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