Pyrrolidine → HCID 11990040, compound

HRID 1157660Notes

Reaction equation

HRID 1157660 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:6][C:7]1[C:14]([CH3:15])=[C:13](F)[CH:12]=[CH:11][C:8]=1[C:9]#[N:10].Cl[C:18]1[CH:25]=[C:24](F)[CH:23]=[CH:22][C:19]=1C#N.FC1C=CC(C#N)=C(C(F)(F)F)C=1>>[Cl:6][C:7]1[C:14]([CH3:15])=[C:13]([N:1]2[CH2:5][CH2:4][CH2:3][CH:2]2[C:18]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:19]=2)[CH:12]=[CH:11][C:8]=1[C:9]#[N:10]

Participants

5

Reactant 4

HCID 31268PyrrolidineHCID 1090002-Chloro-4-fluorobenzonitrileHCID 6050854-Fluoro-2-(trifluoromethyl)benzonitrileHCID 445509712-Chloro-4-fluoro-3-methylbenzonitrile

Product 1

HCID 11990040HCID 11990040, compound

Procedure

Prepare Examples 2 to 20, in the table below, by essentially following the procedures as described in Example 1 above. Use the appropriate pyrrolidine as indicated and 2-chloro-4-fluoro-3-methyl-benzonitrile (Preparation 1), 2-chloro-4-fluorobenzonitrile, or 4-fluoro-2-(trifluoromethyl)benzonitrile.

Workup

  1. customPrepare Examples 2 to 20

Sources & evidence

ORD record
ord-533a8a90b43b4878b8e595df98cdc2b3
Source dataset
uspto-grants-2010_10
Patent number
US07807691B2

Reaction notes

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