Hydrochloric Acid → HCID 12849453, compound

HRID 1157683Notes

Reaction equation

HRID 1157683 reaction equation
[CH3:1][O:2][C@H:3]1[CH2:7][N:6](C(OOC(C)(C)C)=O)[C@@H:5]([C:16]([O-:18])=[O:17])[CH2:4]1.Cl>C1COCC1>[CH3:1][O:2][C@H:3]1[CH2:7][NH:6][C@@H:5]([C:16]([OH:18])=[O:17])[CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86620645HCID 86620645, compound

Product 1

HCID 12849453HCID 12849453, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

10.3 g (48.9 mmol) 1-tert.butoxy (2R,4R)-4-methoxy-pyrrolidine-1,2-dicarboxylate are dissolved in 50 ml THF, 50 ml 6N hydrochloric acid (300 mmol) are added and the mixture is stirred for three hours. The reaction mixture is evaporated to dryness i.vac.

Workup

  1. customThe reaction mixture is evaporated to dryness i.vac

Sources & evidence

ORD record
ord-162602c7c23b406694e93cebeeb30a9e
Source dataset
uspto-grants-2010_10
Patent number
US07807693B2

Reaction notes

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