Hydrochloric Acid → (R)-3-amino-1-methyl-3,4-dihydrocarbostyril hydrochloride

HRID 11585Notes

Reaction equation

HRID 11585 reaction equation
C(OC([NH:8][C@@H:9]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH3:19])[C:10]1=[O:20])=O)(C)(C)C.[ClH:21]>O1CCOCC1>[ClH:21].[NH2:8][C@@H:9]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH3:19])[C:10]1=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69195875(R)-3-t-butyloxycarbonylamino-1-methyl-3,4-dihydrocarbostyril

Product 1

HCID 69196199(R)-3-amino-1-methyl-3,4-dihydrocarbostyril hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(R)-3-t-butyloxycarbonylamino-1-methyl-3,4-dihydrocarbostyril (20 mg) was dissolved in 4 M hydrogen chloride in 1,4-dioxane solution (5 mL) at room temperature. After 1 h the solvent was evaporated under vacuum, and the residue was twice taken up in toluene (5 mL) and evaporated under vacuum to provide (R)-3-amino-1-methyl-3,4-dihydrocarbostyril hydrochloride (25 mg).

Workup

  1. customAfter 1 h the solvent was evaporated under vacuum
  2. customevaporated under vacuum

Sources & evidence

ORD record
ord-7ac6fa017fd64b0fbef0e360df747472
Source dataset
uspto-grants-2006_08
Patent number
US07098235B2

Reaction notes

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