反应详情

A mixture of compound (53) (69 mg, 0.10 mmol), 3-pyridylboronic acid (37 mg, 0.30 mmol), Pd(OAc)2 (1.1 mg, 0.0050 mmol), [(t-Bu)3PH]BF4 (3.0 mg, 0.010 mmol) and K2CO3 (41.5 mg, 0.30 mmol), H2O (0.30 mL) and 1,2-dimethoxyethane (1.0 mL) in a 2.0 mL microwave vial was irradiated to 80° C. for 20 min. The reaction mixture was filtered through celite and the solvent evaporated under reduced pressure. The residue was purified by preparative RP-LC-MS which gave 30.1 mg of the title compound (44% yield) as a colorless solid.

1. customwas irradiated to 80° C. for 20 min
2. filtrationThe reaction mixture was filtered through celite
3. customthe solvent evaporated under reduced pressure
4. customThe residue was purified by preparative RP-LC-MS which