Hydrochloric Acid → HCID 20365130, compound

HRID 1158714Notes

Reaction equation

HRID 1158714 reaction equation
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)=[N:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.Cl>C(OCC)(=O)C>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:11][CH:12]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 68644313HCID 68644313, compound

Product 1

HCID 20365130HCID 20365130, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixed solution of tert-butyl 4-(5-phenylpyridin-2-yl)piperazine-1-carboxylate (800 mg, 2.36 mmol), 2N methanol solution of hydrogen chloride (5 ml) and ethyl acetate (5 ml) was stirred at room temperature for 4 hours, and the solvent was distilled away under reduce pressure. To the residue was added 1N aqueous solution of sodium hydroxide (10 ml), and the titled compound 520 mg (92.1%) was collected by filtration as a solid product.

Workup

  1. distillationthe solvent was distilled away
  2. additionTo the residue was added 1N aqueous solution of sodium hydroxide (10 ml)
  3. filtrationthe titled compound 520 mg (92.1%) was collected by filtration as a solid product

Sources & evidence

ORD record
ord-ffd2859b3d50405db62dd743a5524103
Source dataset
uspto-grants-2010_10
Patent number
US07812025B2

Reaction notes

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