反应详情

A mixed solution of tert-butyl 4-(5-phenylpyridin-2-yl)piperazine-1-carboxylate (800 mg, 2.36 mmol), 2N methanol solution of hydrogen chloride (5 ml) and ethyl acetate (5 ml) was stirred at room temperature for 4 hours, and the solvent was distilled away under reduce pressure. To the residue was added 1N aqueous solution of sodium hydroxide (10 ml), and the titled compound 520 mg (92.1%) was collected by filtration as a solid product.

1. distillationthe solvent was distilled away
2. additionTo the residue was added 1N aqueous solution of sodium hydroxide (10 ml)
3. filtrationthe titled compound 520 mg (92.1%) was collected by filtration as a solid product