1,10-Phenanthroline → tert-Butyl 1-(1-(7-methoxyquinolin-4-yloxy)-2-methylpropan-2-yl)-6-oxo-1,6-dihydropyridin-3-ylcarbamate

HRID 115872Notes

Reaction equation

HRID 115872 reaction equation
[C:35](=[O:36])([O-:37])[O-:38].[Cs+:39].[Cs+:40].[Cu:59][I:60].[I:41][c:42]1[cH:43][cH:44][n:45][c:46]2[cH:47][c:48]([O:52][CH3:53])[cH:49][cH:50][c:51]12.[O:54]=[CH:55][N:56]([CH3:57])[CH3:58].[OH:1][CH2:2][C:3]([CH3:4])([CH3:5])[n:6]1[cH:7][c:8]([NH:13][C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[cH:9][cH:10][c:11]1=[O:12].[cH:21]1[cH:22][c:23]2[cH:24][cH:25][c:26]3[c:27]([c:28]2[n:29][cH:30]1)[n:31][cH:32][cH:33][cH:34]3>>[O:1]([CH2:2][C:3]([CH3:4])([CH3:5])[n:6]1[cH:7][c:8]([NH:13][C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[cH:9][cH:10][c:11]1=[O:12])[c:42]1[cH:43][cH:44][n:45][c:46]2[cH:47][c:48]([O:52][CH3:53])[cH:49][cH:50][c:51]12

Participants

8

Reactant 7

HCID 13181,10-PhenanthrolineHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 177506514-Iodo-7-methoxyquinolineHCID 69231018tert-Butyl 1-(1-hydroxy-2-methylpropan-2-yl)-6-oxo-1,6-dihydropyridin-3-ylcarbamate

Product 1

HCID 59843045tert-Butyl 1-(1-(7-methoxyquinolin-4-yloxy)-2-methylpropan-2-yl)-6-oxo-1,6-dihydropyridin-3-ylcarbamate

Sources & evidence

ORD record
ord-989eb8d4446341378dac986923a52d0a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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