4-Desoxypyridoxine hydrochloride → HCID 68644250, compound

HRID 1158936Notes

Reaction equation

HRID 1158936 reaction equation
[CH3:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][N:5]=[C:4]([CH3:10])[C:3]=1[OH:11].Cl.Br[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[CH:17][CH:16]=1>>[OH:9][CH2:8][C:7]1[C:2]([CH3:1])=[C:3]([O:11][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[CH:17][CH:16]=2)[C:4]([CH3:10])=[N:5][CH:6]=1

Participants

3

Reactant 2

HCID 674174-Desoxypyridoxine hydrochlorideHCID 869964-(Bromomethyl)benzonitrile

Product 1

HCID 68644250HCID 68644250, compoundYield 80.3%

Procedure

The coupling of 4-deoxypyridoxine hydrochloride (5.0 g, 0.026 mol) and α-bromo-p-tolunitrile (5.2 g, 0.026 mol), as described in Example 3, gave 4-(5-hydroxymethyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile (22) (5.6 g, 80% yield) as a colorless solid.

Sources & evidence

ORD record
ord-024099c7767b4ea798a0636a1b9f4b86
Source dataset
uspto-grants-2010_10
Patent number
US07812037B2

Reaction notes

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