4-Cyanophenol → HCID 58636822, compound

HRID 1158956Notes

Reaction equation

HRID 1158956 reaction equation
[OH:1][CH2:2][C:3]1[C:4]([CH3:20])=[C:5]([O:10][CH2:11][C:12]2[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=2)[C:15]#[N:16])[C:6]([CH3:9])=[N:7][CH:8]=1.[C:21]([C:23]1[CH:28]=[CH:27][C:26](O)=[CH:25][CH:24]=1)#[N:22]>>[CH3:20][C:4]1[C:5]([O:10][CH2:11][C:12]2[CH:19]=[CH:18][CH:17]=[C:14]([C:15]#[N:16])[CH:13]=2)=[C:6]([CH3:9])[N:7]=[CH:8][C:3]=1[CH2:2][O:1][C:26]1[CH:27]=[CH:28][C:23]([C:21]#[N:22])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 130194-CyanophenolHCID 586368033-(5-Hydroxymethyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile

Product 1

HCID 58636822HCID 58636822, compoundYield 47.3%

Procedure

The coupling of 3-(5-hydroxymethyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile (26) (1.0 mg, 3.70 mmol) and 4-cyanophenol (885 mg, 7.40 mmol), as described in Example 9, gave 4-[4,6-dimethyl-5-(3-cyano-benzyloxy)-pyridin-3-ylmethoxy]-benzonitrile (69) (646 mg, 47% yield).

Sources & evidence

ORD record
ord-2a1c678de0354532b74b62012f3f1673
Source dataset
uspto-grants-2010_10
Patent number
US07812037B2

Reaction notes

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