Hydrochloric Acid → HCID 131726534, compound

HRID 1159014Notes

Reaction equation

HRID 1159014 reaction equation
C(OC([N:8]1[CH2:24][CH2:23][N:11]2[CH2:12][C:13]3[C:18]([C@@H:10]2[CH2:9]1)=[CH:17][CH:16]=[CH:15][C:14]=3[C:19]([F:22])([F:21])[F:20])=O)(C)(C)C.[ClH:25]>>[ClH:25].[ClH:25].[F:21][C:19]([F:20])([F:22])[C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:13]=1[CH2:12][N:11]1[CH2:23][CH2:24][NH:8][CH2:9][C@H:10]12

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68691015HCID 68691015, compound

Product 1

HCID 131726534HCID 131726534, compoundYield 99%

Procedure

To N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-7-trifluoromethyl-pyrazino[2,1-a]isoindole (37 mg, 0.11 mmol) was added concentrated aqueous hydrogen chloride (1 mL). After 15 min, the solution was concentrated, diluted with water, and lypholized to give (R)-1,3,4,10b-tetrahydro-7-trifluoromethyl-pyrazino[2,1-a]isoindole bis hydrochloric acid salt (33 mg, 99%) as an off white solid.

Workup

  1. concentrationthe solution was concentrated
  2. additiondiluted with water

Sources & evidence

ORD record
ord-3f69fff13843462da74adbbaf5f49ec6
Source dataset
uspto-grants-2010_10
Patent number
US07812024B2

Reaction notes

Loading…