2-Aminothiazole → HCID 59513987, compound

HRID 1159135Notes

Reaction equation

HRID 1159135 reaction equation
N1[C:9]2[C:4](=CC=[CH:7][CH:8]=2)C=N1.CO[C:12]([C:14]1[C:22]2[C:17](=[N:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1)=[O:13].C1(CBr)CC1.[NH2:28][C:29]1[S:30][CH:31]=[CH:32][N:33]=1>>[S:30]1[CH:31]=[CH:32][N:33]=[C:29]1[NH:28][C:12]([C:14]1[C:22]2[C:17](=[N:18][CH:19]=[CH:20][CH:21]=2)[N:16]([CH2:4][CH:9]2[CH2:8][CH2:7]2)[CH:15]=1)=[O:13]

Participants

5

Reactant 4

HCID 21552-AminothiazoleHCID 92211H-IndazoleHCID 81503BromomethylcyclopropaneHCID 21110084methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate

Product 1

HCID 59513987HCID 59513987, compound

Procedure

Azaindole starting material=1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; R5X=cyclopropyl-methylbromide; NH2A=2-aminothiazole

Sources & evidence

ORD record
ord-8f97a031c46f464690c7b2b0e80ce6fd
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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