Bromomethylcyclopropane → Indole

HRID 1159147Notes

Reaction equation

HRID 1159147 reaction equation
F[C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.C1(CBr)CC1.N1C=CC=CC=1SC1SC(N)=NC=1>>[NH:8]1[C:9]2[C:5](=[CH:4][CH:3]=[CH:2][CH:10]=2)[CH:6]=[CH:7]1

Participants

4

Reactant 3

HCID 81503BromomethylcyclopropaneHCID 3512786-FluoroindoleHCID 157291575-(Pyridin-2-ylsulfanyl)-thiazol-2-ylamine

Product 1

HCID 798Indole

Procedure

6-fluoroindole, R5X=cyclopropyl-methylbromide; NH2A=5-(pyridin-2-ylsulfanyl)-thiazole-2-ylamine

Sources & evidence

ORD record
ord-5563f6bea4cd43b79f848bad42ba2dfc
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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