Bromomethylcyclopropane → Indole

HRID 1159150Notes

Reaction equation

HRID 1159150 reaction equation
FC(F)(F)[C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][NH:9]2)=[CH:5][CH:4]=1.C1(CBr)CC1.C(OC(=O)CSC1SC(N)=NC=1)C>>[NH:9]1[C:10]2[C:6](=[CH:5][CH:4]=[CH:3][CH:11]=2)[CH:7]=[CH:8]1

Participants

4

Reactant 3

HCID 81503BromomethylcyclopropaneHCID 27775236-(Trifluoromethyl)indoleHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetate

Product 1

HCID 798Indole

Procedure

6-trifluoromethylindole, R5X=cyclopropyl-methylbromide; NH2A=(2-amino-thiazole-5-ylsulfanyl)-acetic acid ethyl ester

Sources & evidence

ORD record
ord-5324eee8ae2f4102823a0f1e8f61d00f
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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