Bromomethylcyclopropane → Indole

HRID 1159155Notes

Reaction equation

HRID 1159155 reaction equation
C[C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.C1(CBr)CC1.C(OC(=O)C(SC1SC(N)=NC=1)C)C>>[NH:8]1[C:9]2[C:5](=[CH:4][CH:3]=[CH:2][CH:10]=2)[CH:6]=[CH:7]1

Participants

4

Reactant 3

HCID 81503BromomethylcyclopropaneHCID 1379281H-Indole, 6-methyl-HCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl ester

Product 1

HCID 798Indole

Procedure

6-methylindole, R5X=cyclopropyl-methylbromide; NH2A=(2-amino-thiazole-5-ylsulfanyl)-propionic acid ethyl ester

Sources & evidence

ORD record
ord-49d800e9ac05466fb6acd438783fcd14
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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