Bromomethylcyclopropane → Indole

HRID 1159159Notes

Reaction equation

HRID 1159159 reaction equation
COC[C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1.C1(CBr)CC1.C(OC(=O)C(SC1SC(N)=NC=1)C)C>>[NH:10]1[C:11]2[C:7](=[CH:6][CH:5]=[CH:4][CH:12]=2)[CH:8]=[CH:9]1

Participants

4

Reactant 3

HCID 81503BromomethylcyclopropaneHCID 23080881HCID 23080881, compoundHCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl ester

Product 1

HCID 798Indole

Procedure

6-methoxymethylindole, R5X=cyclopropyl-methylbromide; NH2A=(2-amino-thiazole-5-ylsulfanyl)-propionic acid ethyl ester

Sources & evidence

ORD record
ord-7e8d1e8c7d1b46f29ad8bc2a1f3ae560
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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