2-Aminothiazole → HCID 58217461, compound

HRID 1159170Notes

Reaction equation

[I-].[Na+].[CH3:3][C:4](=[CH2:18])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]([OH:17])=O)=[N:7]1.[NH2:19][C:20]1[S:21][CH:22]=[CH:23][N:24]=1>>[S:21]1[CH:22]=[CH:23][N:24]=[C:20]1[NH:19][C:15]([C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:6]([CH2:5][C:4]([CH3:3])=[CH2:18])[N:7]=1)=[O:17]

Participants

Reactant 3

HCID 21552-Aminothiazole

HCID 5238Sodium Iodide

HCID 18695551HCID 18695551, compound

Product 1

HCID 58217461HCID 58217461, compoundYield 23.2%

Procedure

1-(2-Methylallyl)-indazole-3-carboxylic acid (440 mg) was obtained from methyl indazole-3-carboxylate (0.5 g, 2.84 mmol) and 1-chloro-2-methylpropene (0.28 mL, 2.84 mmol, with a catalytic amount of sodium iodide) following the general procedures G and E. 1-(2-Methylallyl)-indazole-3-carboxylic acid thiazol-2-ylamide (45 mg) was prepared from 1-(2-methylallyl)-indazole-3-carboxylic acid (140 mg, 0.65 mmol) and 2-aminothiazole (65 mg, 0.65 mmol) following the general procedure H.

Sources & evidence

ORD record: ord-5ae2657d222c4c77a40887f2c4e5aa76
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07812043B2

Reaction notes

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