2-Aminothiazole → HCID 20483867, compound

HRID 1159172Notes

Reaction equation

HRID 1159172 reaction equation
N1C=CC=C1C(OCC)=O.C(I)CCC.[CH2:16]([N:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:25]([OH:27])=[O:26])[CH2:17][CH2:18][CH3:19].[NH2:28][C:29]1[S:30][CH:31]=[CH:32][N:33]=1>>[CH2:16]([N:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:25]([OH:27])=[O:26])[CH2:17][CH2:18][CH3:19].[S:30]1[CH:31]=[CH:32][N:33]=[C:29]1[NH:28][C:25]([C:21]1[N:20]([CH2:16][CH2:17][CH2:18][CH3:19])[CH:24]=[CH:23][CH:22]=1)=[O:27]

Participants

6

Reactant 4

HCID 21552-AminothiazoleHCID 10962Butyl iodideHCID 255670Ethyl 1H-pyrrole-2-carboxylateHCID 20483867HCID 20483867, compound

Product 2

HCID 20483867HCID 20483867, compoundHCID 59513961HCID 59513961, compound

Procedure

1-Butyl-pyrrole-2-carboxylic acid (130 mg) was prepared from ethyl pyrrole-2-carboxylate (139 mg, 1.0 mmol) and butyl iodide (0.12 mL, 1.0 mmol) following general procedures D and E. 1-Butyl-pyrrole-2-carboxylic acid thiazol-2-ylamide (100 mg) was prepared from 1-butyl-pyrrole-2-carboxylic acid (130 mg, 0.77 mmol) and 2-aminothiazole (80 mg, 0.80 mmol) following general procedure F.

Sources & evidence

ORD record
ord-6b8c59e0c2f04432b17cef3026f0dc26
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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