Hydrochloric Acid → HCID 68445147, compound

HRID 1159477Notes

Reaction equation

HRID 1159477 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:15]=[CH:14][C:6]2[C:7]([O:10]C(=O)C)=[CH:8][O:9][C:5]=2[CH:4]=1.CO.Cl>O>[F:17][C:2]([F:1])([F:16])[C:3]1[CH:15]=[CH:14][C:6]2[C:7](=[O:10])[CH2:8][O:9][C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 68443656HCID 68443656, compound

Product 1

HCID 68445147HCID 68445147, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of acetic acid 6-trifluoromethyl-benzofuran-3-yl ester (15 g), methanol (100 ml), water (53.8 ml) and 1 N HCl (18.8 ml) was heated at reflux for 6 hrs. Mixture was cooled to room temperature. Crude product was evaporated in vacuo and purified by chromatography to give product 6a (Hexane:EA=18:1).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 6 hrs
  3. customCrude product was evaporated in vacuo
  4. custompurified by chromatography

Sources & evidence

ORD record
ord-f8e148b6579b46eb87406bfd05dac2e3
Source dataset
uspto-grants-2010_10
Patent number
US07812177B2

Reaction notes

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