Methyl formate → N'-(4-Bromophenyl)formohydrazide

HRID 1159639Notes

Reaction equation

HRID 1159639 reaction equation
Cl.[Br:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.[C:11]([O-])([O-])=[O:12].[K+].[K+].C(OC)=O>O>[Br:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH:10][CH:11]=[O:12])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 7865Methyl formateHCID 11430Potassium CarbonateHCID 121574-Bromophenylhydrazine hydrochloride

Product 1

HCID 13725233N'-(4-Bromophenyl)formohydrazide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 g of 4-bromophenylhydrazine hydrochloride are dissolved in 30 ml of water; 6.2 g of K2CO3 and 36 ml of methyl formate are added and then the mixture is heated at reflux for 1 hour and then at AT for 12 hours. The precipitate formed is filtered off and then washed with an isopropanol/PE mixture (50/50; v/v). This gives 10.5 g of the expected compound.

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 1 hour
  3. customThe precipitate formed
  4. filtrationis filtered off
  5. washwashed with an isopropanol/PE mixture (50/50; v/v)

Sources & evidence

ORD record
ord-7d3c43a5e55240858f88758845a1dab7
Source dataset
uspto-grants-2010_10
Patent number
US07812165B2

Reaction notes

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