Ethanol → Ethyl 3-(bromophenyl)acetate

HRID 1159642Notes

Reaction equation

HRID 1159642 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[CH2:17](O)[CH3:18]>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:17][CH3:18])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 74653(3-Bromophenyl)acetic acid

Product 1

HCID 11470552Ethyl 3-(bromophenyl)acetate

Procedure

5 g of 3-bromophenylacetic acid are dissolved in 80 ml of ethanol, 3 ml of concentrated H2SO4 are added and then the solution is heated at reflux for 2 hours. The ethanol is evaporated and the residue is neutralized with saturated K2CO3 solution and then extracted with AcOEt and dried over MgSO4. This gives 5.2 g of the expected compound in liquid form.

Workup

  1. temperaturethe solution is heated
  2. temperatureat reflux for 2 hours
  3. customThe ethanol is evaporated
  4. extractionextracted with AcOEt
  5. dry with materialdried over MgSO4

Sources & evidence

ORD record
ord-208d703ca4284f048e6779d430a5e77a
Source dataset
uspto-grants-2010_10
Patent number
US07812165B2

Reaction notes

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