Trifluoroacetic acid → HCID 86618246, compound

HRID 1159800Notes

Reaction equation

HRID 1159800 reaction equation
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([CH2:19][N:20]4[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH:22]([C:33]([O:35][CH3:36])=[O:34])[CH2:21]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:37]([OH:43])([C:39]([F:42])([F:41])[F:40])=[O:38]>ClCCl>[F:40][C:39]([F:42])([F:41])[C:37]([OH:43])=[O:38].[F:40][C:39]([F:42])([F:41])[C:37]([OH:43])=[O:38].[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([CH2:19][N:20]4[CH2:25][CH2:24][NH:23][CH:22]([C:33]([O:35][CH3:36])=[O:34])[CH2:21]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68718016HCID 68718016, compound2×

Product 1

HCID 86618246HCID 86618246, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-tert-Butyl 2-methyl 4-{[1-(phenylsulfonyl)-1H-indol-4-yl]methyl}piperazine-1,2-dicarboxylate (0.013 g, 0.025 mmol, Intermediate 50) was dissolved in dichloromethane (1 mL) and TFA (0.5 mL) was added. The mixture was stirred for 1 h and evaporated. Yield: 16 mg (100%). Colorless oil. MS (electronspray; [M+H]+) m/z 414.6.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-94e5bbea72d94f4895100cee765d00d3
Source dataset
uspto-grants-2010_10
Patent number
US07812017B2

Reaction notes

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