反应详情

To a slurry of sodium hydride (165 mg, 6.9 mmol) in DMF (5 ml) indole-4-carboxaldehyde (500 mg, 3.4 mmol) was added. The mixture was stirred for 15 min and then the 2-methoxy-5-methyl-benzenesulfonyl chloride (1140 mg, 5.2 mmol) was added and the mixture was stirred for 1 h at room temperature. Water was added and the reaction mixture was extracted with EtOAc. Evaporation gave 1.2 g. MS (ESI+) for C17H15NO4S m/z 330 (M+H)+.

1. stirringthe mixture was stirred for 1 h at room temperature
2. extractionthe reaction mixture was extracted with EtOAc
3. customEvaporation
4. customgave 1.2 g