Hydrochloric Acid → HCID 59513832, compound

HRID 1159965Notes

Reaction equation

HRID 1159965 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:33])[C:25]4[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=4[F:32])[CH:20]=[CH:21][CH:22]=3)=[N:10][N:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=23)[CH:5]=[CH:4][N:3]=1.[CH3:34][N:35]([CH3:48])[CH2:36][CH2:37][O:38][C:39]1[CH:40]=[C:41]([CH:43]=[CH:44][C:45]=1[O:46][CH3:47])[NH2:42].Cl>C(O)(C)C>[CH3:48][N:35]([CH3:34])[CH2:36][CH2:37][O:38][C:39]1[CH:40]=[C:41]([NH:42][C:2]2[N:7]=[C:6]([C:8]3[C:9]([C:17]4[CH:18]=[C:19]([NH:23][C:24](=[O:33])[C:25]5[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=5[F:32])[CH:20]=[CH:21][CH:22]=4)=[N:10][N:11]4[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=34)[CH:5]=[CH:4][N:3]=2)[CH:43]=[CH:44][C:45]=1[O:46][CH3:47]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 105603983-(2-(Dimethylamino)ethoxy)-4-methoxyanilineHCID 59513803N-{3-[3-(2-Chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide

Product 1

HCID 59513832HCID 59513832, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide (prepared according to a procedure similar to that described in Example 27, Step C) and 3-{[2-(dimethylamino)ethyl]oxy}-4-(methyloxy)aniline were heated in isopropanol with catalytic conc. aq. HCl using conditions similar to those described in Example 27, Step D. HRMS C35H32N7O3F2 (M+H)+ calcd 636.2535, found 636.2527.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-7a7f69ff5733435a8aa2001f870acb89
Source dataset
uspto-grants-2010_10
Patent number
US07812022B2

Reaction notes

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