Hydrochloric Acid → HCID 11671541, compound

HRID 1160013Notes

Reaction equation

HRID 1160013 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:33])[C:25]4[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:26]=4[F:32])[CH:20]=[CH:21][CH:22]=3)=[N:10][N:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=23)[CH:5]=[CH:4][N:3]=1.[NH2:34][C:35]1[CH:44]=[CH:43][C:38]2[N:39]=[CH:40][CH2:41][O:42][C:37]=2[CH:36]=1.Cl.C([OH:49])(C)C>>[F:32][C:26]1[CH:27]=[CH:28][CH:29]=[C:30]([F:31])[C:25]=1[C:24]([NH:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:9]2[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([NH:34][C:35]4[CH:44]=[CH:43][C:38]5[NH:39][C:40](=[O:49])[CH2:41][O:42][C:37]=5[CH:36]=4)[N:7]=3)=[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][N:11]3[N:10]=2)[CH:18]=1)=[O:33]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 59513803N-{3-[3-(2-Chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamideHCID 66759533HCID 66759533, compound

Product 1

HCID 11671541HCID 11671541, compound

Procedure

A mixture of N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide (which may be prepared according to a procedure similar to Example 27, Step C) and 7-amino-2H1,4-benzoxazin-3(4H-one are heated in isopropanol with catalytic conc. HCl at approximately 85° C. to afford the product. ES-LCMS m/z 590 (M+H).

Workup

  1. custommay be prepared
  2. customto afford the product

Sources & evidence

ORD record
ord-9d53bf7a43e94057adcad1d800349523
Source dataset
uspto-grants-2010_10
Patent number
US07812022B2

Reaction notes

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