反应详情

To a solution of 3-benzyl-3-[(diphenylmethylene)amino]dihydrofuran-2(3H)-one (5.67 g, 15.95 mmol) in MeOH (50 mL) and THF (50 mL) was added 6N HCl (5.3 mL, 32 mmol). After 5 min stirring at RT, the reaction mixture was concentrated in vacuo, diluted with water and benzophenone was extracted with diethyl ether (3×). The aqueous layer was basified to pH 10 with 6N NaOH, extracted with DCM (×2), dried over sodium sulfate and concentrated in vacuo to give 3-amino-3-benzyldihydrofuran-2(3H)-one as a colorless oil, which was carried as is in the next step.

1. concentrationthe reaction mixture was concentrated in vacuo
2. additiondiluted with water and benzophenone
3. extractionwas extracted with diethyl ether (3×)
4. extractionextracted with DCM (×2)
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo